Effects of Terminalia chebula on the Larval Crawling Ability of Drosophila melanogaster
Author : Priyanka S and Shakunthala V
Abstract :
The study investigates the impact of Terminalia chebula (T. chebula) on the larval crawling ability and overall locomotion of Drosophila melanogaster. As concentrations of T. chebula extract increase, a significant reduction in both crawling ability and general locomotor activity of the larvae is observed. This decline in motor function and locomotion is hypothesized to result from factors like lipid accumulation due to enhanced feeding and potential neurotoxicity induced by certain phytoconstituents present in the extract. The lipid accumulation is suggested to impair energy metabolism and physical movement, thereby reducing overall locomotion, while the neurotoxic effects at higher concentrations might directly affect the nervous system, leading to impaired motor coordination and crawling ability. Despite these findings, the precise molecular mechanisms underlying these observed effects remain unclear and warrant further research. Elucidating these mechanisms could provide valuable insights into the biological activity of T. chebula and its implications for locomotor and neurological health. This study underscores the importance of a detailed analysis of the interaction between phytochemicals and physiological processes in model organisms like Drosophila melanogaster.
Keywords :
Terminalia chebula, Drosophila melanogaster, Larval Crawling
