Penoxsulam Herbicide Microbiological and Toxicological Assessment on Soil Microorganisms and Animal Model
Author : Dr. Sudhakar Rai
Abstract :
Objective: The aim of this study involves:
a) Pseudomonas isolates from soil samples are isolated and identified
b) Penoxsulam's bactericidal activity against Pseudomonas isolates is assessed,
c) Penoxsulam's animal model pre-clinical investigation,
d) Making sense of the facts to improve human welfare through raising awareness among the populace.
Method: Following the isolation and identification of Pseudomonas F from soil samples, four concentrations of penoxsulam-25 mg, 50 mg, 100 mg, and 200 mg-were tested for bactericidal efficacy. In order to assess an acute oral study in which animals were administered using an intubation cannula with a single dose level of 2000 mg/kg body weight and observed for 14 days, rabbits' eyes were exposed to Penoxsulam herbicide. This herbicide was carefully administered in the conjunctival sac of the left eye of the rabbit and examined for 7 days.
Result: No changes were found in body weight of rat and rabbit whereas Penoxsulam herbicide at a 100mg concentration had bactericidal activity and also toxic to rabbit eye rather than oral ingestion.
Conclusion: The results demonstrated that the herbicide Penoxsulam has bactericidal activity at a dosage of 100 mg. Overall, our results showed that penoxsulam did not appear to cause acute oral toxicity but was toxic to animal eyes and appeared to be damaging to eyes in the environment.
Keywords :
Penoxsulam, bactericidal activity, wistar rats, oral toxicity
